Relation of the amyloid beta protein precursor to heparan sulfate proteoglycans
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چکیده
منابع مشابه
Relation of the amyloid beta protein precursor to heparan sulfate proteoglycans.
the differences between the leukemic and remission samples of this patient. Miller et al. and Donti et al. suggest that the conclusions of our paper imply an understanding of the pathogenesis of APL or a direct association between rearranged MPO and critical DNA sequences involved in the t(15;17); this is not the case. Although questioned, it should be noted that only "one explanation for the p...
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Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and core...
متن کاملHeparan sulfate proteoglycans
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of heparan sulfate (HS) proteoglycans (HSPGs) in early embryogenesis, morphogenesis, angiogenesis, and epithelial-mesenchymal interactions (1–3). HS chains bind a multitude of proteins and ensure that a wide variety of bioactive molecules (e.g., heparin-binding growth factors...
متن کاملInteraction between beta-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer's disease.
Proteoglycans are important in the pathogenesis of senile dementia of Alzheimer type (SDAT) by participating in amyloidogenesis. Knowledge about specific proteoglycan subtypes in SDAT may be of therapeutic advantage. In this study, we examined proteoglycan constituents of SDAT brains with reference to hyaluronic acid, heparan sulfate (HS), dermatan sulfate and chondroitin sulfate subtypes. Tota...
متن کاملHeparan Sulfate Proteoglycans in Infection
To cause infections, microbial pathogens elaborate a multitude of factors that interact with host components. Using these host–pathogen interactions to their advantage, pathogens attach, invade, disseminate, and evade host defense mechanisms to promote their survival in the hostile host environment. Many viruses, bacteria, and parasites express adhesins that bind to cell surface heparan sulfate...
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ژورنال
عنوان ژورنال: Science
سال: 1989
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.2499044